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Medication Dosage & Guidelines

How To Inject Medication

 

 

 

 

 

Injectable Antibiotics for Koi Fish

  Injectable antibiotics are commonly used to treat koi fish with internal bacterial infections, wounds, or systemic illnesses.    Unlike medicated dips, which primarily treat external issues, injectable antibiotics are directly administered to the fish,   providing more targeted and effective treatment for more serious infections. Below are some of the most commonly used injectable antibiotics for koi fish:

 

1. Amikacin

  • Type: Aminoglycoside antibiotic.

  • Effective Against: Gram-negative bacteria (Aeromonas, Pseudomonas).

  • Administration: Intramuscular (IM) or intraperitoneal (IP).

  • Dosage: 2-5 mg/kg of fish body weight.

  • Frequency: Once every 48-72 hours.

  • Notes: Use with caution in fish with kidney issues as aminoglycosides can be nephrotoxic.

2. Ampicillin

  • Type: Broad-spectrum beta-lactam antibiotic.

  • Effective Against: Gram-positive and some gram-negative bacteria.

  • Administration: IM or IP.

  • Dosage: 20-50 mg/kg of fish body weight.

  • Frequency: Once every 24 hours for 3-5 days.

  • Notes: Effective for gram-positive infections; avoid use in fish with known beta-lactam allergies.

3. Ceftazidime

  • Type: Cephalosporin antibiotic.

  • Effective Against: Aeromonas and other bacterial infections.

  • Administration: IM or IP.

  • Dosage: 20 mg/kg of fish body weight.

  • Frequency: Every 48-72 hours for 3-5 doses.

  • Notes: Excellent choice for resistant infections.

4. Chloramphenicol

  • Type: Broad-spectrum antibiotic.

  • Effective Against: Resistant gram-positive and gram-negative bacteria.

  • Administration: IM.

  • Dosage: 30-50 mg/kg of fish body weight.

  • Frequency: Every 48-72 hours for 2-4 doses.

  • Notes: Use is restricted in some regions due to human health concerns.

5. Enrofloxacin (Baytril)

  • Type: Broad-spectrum antibiotic.

  • Effective Against: Aeromonas, Pseudomonas, and Flavobacterium columnare.

  • Administration: IM or IP.

  • Dosage: Typically 5-10 mg/kg of fish body weight.

  • Frequency: Once every 24-48 hours for 3-5 doses.

  • Notes: Widely used for koi; good tissue penetration and low toxicity.

6. Florfenicol (Nuflor)

  • Type: Broad-spectrum antibiotic.

  • Effective Against: Aeromonas and Pseudomonas.

  • Administration: IM.

  • Dosage: 20 mg/kg of fish body weight.

  • Frequency: Every 48 hours for 2-3 doses.

  • Notes: Excellent for systemic infections with low risk of adverse effects.

7. Oxytetracycline

  • Type: Broad-spectrum tetracycline antibiotic.

  • Effective Against: Many gram-positive and gram-negative bacteria.

  • Administration: IM.

  • Dosage: 20-40 mg/kg of fish body weight.

  • Frequency: Once every 72 hours for 3-4 doses.

  • Notes: May cause irritation at the injection site; avoid prolonged use.

8. Trimethoprim-Sulfadiazine (Tribrissen)

  • Type: Sulfonamide antibiotic combination.

  • Effective Against: Gram-negative and some gram-positive bacteria.

  • Administration: IM or IP.

  • Dosage: 30-50 mg/kg of fish body weight.

  • Frequency: Once daily for 5-7 days.

  • Notes: Safe for use in fish; often used as an alternative to Enrofloxacin.

Injectable Antibiotics

Intramuscular Injection

Intraperitoneal Injection

Medicated Dips

Medicated Dips

Medicated dips are commonly used for treating a variety of koi fish illnesses, especially for conditions involving external parasites, bacterial infections, or wounds. Here are some of the most common medicated dips used in koi treatment:

 

1. Potassium Permanganate (PP)

  • Purpose: Potassium permanganate is a powerful oxidizing agent that helps to treat a variety of external parasites, fungal infections, and bacterial issues. It's also used for cleaning the pond and water environment.

  • Common Uses: External parasites (like Costia, Trichodina), fungal infections, improving overall water quality.

  • Dosage: Typically 2 ppm for 4-6 hours, but dosage varies depending on the severity of the infection and the size of the koi.

2. Formalin-Malachite Green

  • Purpose: A combination of two chemicals, Formalin and Malachite Green, is used to treat external parasites like ich (Ichthyophthirius multifiliis) and costia. Malachite Green is a potent anti-parasitic, while Formalin is effective in treating external protozoan infections.

  • Common Uses: Treating external protozoan parasites like Ich, Trichodina, and Oodinium.

  • Dosage: Varies depending on the product, but usually 25-50 mg/L for 30-60 minutes.

3. Acriflavine

  • Purpose: Acriflavine is an anti-fungal and anti-bacterial agent. It helps with the treatment of skin wounds, ulcers, and external fungal infections. It is commonly used to treat koi with minor injuries or mild external infections.

  • Common Uses: Fungal infections, minor skin lesions, and ulcers.

  • Dosage: Typically 10-15 mg/L for a 10-15 minute bath, but follow the manufacturer's instructions.

4. Copper Sulfate

  • Purpose: Copper sulfate is commonly used for treating external parasites like gill flukes and certain types of protozoa.

  • Common Uses: Treating parasites such as gill flukes, external protozoans (e.g., Trichodina).

  • Dosage: Usually 1-2 ppm, depending on the specific condition and product used. Prolonged exposure or overdosing can be harmful, so careful dosing is essential.

5. Hydrogen Peroxide (3%)

  • Purpose: Hydrogen peroxide is an antiseptic and disinfectant that helps clean wounds, ulcers, and infected skin areas. It’s used as a topical dip to cleanse affected areas before applying other treatments.

  • Common Uses: Treating external wounds, ulcers, and injuries.

  • Dosage: Use a diluted solution of 1:10 ratio (1 part hydrogen peroxide to 10 parts water) for a 5-10 minute dip.

6. Salt (Non-Iodized)

  • Purpose: Non-iodized salt is commonly used in koi treatment for stress reduction, osmoregulation, and minor external bacterial infections. It is effective in improving mucus production and reducing the impact of external stressors.

  • Common Uses: Minor bacterial infections, parasite treatment, and as a stress reliever.

  • Dosage: 0.3-0.5% salt solution (3-5 grams per liter of water) for a 10-15 minute dip.

7. Malachite Green (Solo)

  • Purpose: Malachite Green is commonly used to treat external parasites, including protozoans like ich (Ichthyophthirius multifiliis) and other skin parasites.

  • Common Uses: External parasites such as Ich, Oodinium, and Trichodina.

  • Dosage: Typically, 2.5 mg/L for 30 minutes, but this can vary depending on the concentration of the solution and the fish's tolerance.

8. Chloramine-T

  • Purpose: Chloramine-T is used to treat bacterial and fungal infections. It also helps to reduce the amount of parasites in the koi's environment.

  • Common Uses: Bacterial infections, fungal infections, and certain external parasites.

  • Dosage: Usually 0.5-1.0 g/L for a 30-60 minute bath, following manufacturer guidelines.

9. Methylene Blue

  • Purpose: Methylene Blue is effective for treating fungal and protozoan infections, and can also be used for external wounds and ulcers.

  • Common Uses: Fungal infections, treating skin wounds, external protozoan infections.

  • Dosage: Typically 1-2 mg/L for 30-60 minutes.

10. Iodine-Based Dips

  • Purpose: Iodine-based dips are used to treat minor external infections, including bacterial and fungal issues.

  • Common Uses: Wounds, cuts, and external fungal infections.

  • Dosage: Dilute iodine to a 1:1000 or 1:2000 ratio for short dips of 5-10 minutes.

Important Considerations When Using Medicated Dips

  • Always follow the manufacturer's instructions on dosing, as overdosing can harm the koi.

  • Make sure to perform the dip in a clean quarantine tank, and always ensure the water is dechlorinated and at the appropriate temperature (Match temperature of dip tank and recovery tank to quarantine tank, sudden temperature changes creates undo stress on fish ).

  • After a medicated dip, observe the koi carefully for signs of stress or improvement.

  • Perform the dips in short sessions, usually 10-15 minutes, depending on the treatment.

By using the appropriate medicated dips and ensuring proper water conditions, koi owners can effectively address common external infections and promote better recovery.

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Pond-wide treatments are sometimes necessary to address widespread koi health issues, such as parasites or infections. However, it’s always best to treat individual fish in a quarantine system first to avoid disturbing the pond’s biofilter. Treating the entire pond can affect the delicate balance of beneficial bacteria, so isolating sick fish and using targeted treatments is the preferred method

  1. Potassium Permanganate (PP)

    • Targets:

      • Parasites: Costia (Ichthyobodo), Chilodonella, Trichodina, and flukes (gill and skin flukes).

      • Other Uses: Effective against bacteria and fungi.

    • Impact on Biofilter:

      • Potassium permanganate is an oxidizer that can harm beneficial bacteria if overdosed or used repeatedly in a short time.

      • Aeration is critical to protect the nitrogen cycle.

    • Recommendation: Use with caution and monitor ammonia/nitrite levels after treatment. Follow up with partial water changes and water testing.

  2. Malachite Green and Formalin (Combination)

    • Targets:

      • Parasites: Ich (white spot disease), Costia, Chilodonella, Trichodina, and some flukes.

    • Impact on Biofilter:

      • Can suppress beneficial bacteria if overdosed.

      • Prolonged or repeated treatments may harm the biological filter and disrupt the nitrogen cycle.

    • Recommendation: Avoid use in ponds with scaleless fish or weak filtration. Treat in a quarantine tank if possible.

  3. Praziquantel

    • Targets:

      • Parasites: Flukes (gill and skin), and some types of tapeworms in fish.

    • Impact on Biofilter:

      • Safe and does not disrupt biological filtration.

    • Recommendation: Suitable for use in biologically balanced ponds. Ensure proper dosing to avoid waste.

  1. Dimilin (Diflubenzuron)

    • Targets:

      • Parasites: Anchor worms (Lernaea) and fish lice (Argulus).

    • Impact on Biofilter:

      • Does not harm beneficial bacteria or biological filtration.

    • Recommendation: Safe for use in established ponds but ensure that the correct dosage is applied.

  1. Salt (Non-Iodized)

    • Targets:

      • Parasites: Costia, Chilodonella, Trichodina, and some flukes (gill and skin).

    • Impact on Biofilter:

      • Therapeutic levels (0.3–0.5%) generally do not harm beneficial bacteria.

      • High concentrations above 0.5% may reduce biofilter efficiency.

    • Recommendation: Use within recommended levels and monitor water parameters closely.

  1. Copper-Based Treatments (Chelated Copper)

    • Targets:

      • Parasites: Ich, Costia, Trichodina, and some flukes.

    • Impact on Biofilter:

      • Copper can inhibit beneficial bacteria and disrupt the nitrogen cycle at higher doses.

      • May also stress sensitive fish, such as koi and scaleless fish.

    • Recommendation: Avoid using copper in main ponds with established filtration. Better suited for quarantine tanks.

                    General Guidelines for Pond-Wide Anti-Parasitic Treatment

  • Aeration: Increase aeration during and after treatment to prevent oxygen depletion caused by some medications.

  • Water Testing: Regularly monitor ammonia, nitrite, and nitrate levels during and after treatment.

  • Partial Water Changes: Perform 20–30% water changes post-treatment to reduce residual medication.

  • Beneficial Bacteria: Consider adding bacterial supplements (e.g., Microbe-Lift, Pondzyme) to replenish any damaged biofilters.

  • Quarantine Option: If possible, treat infected fish in a separate tank to minimize the impact on the pond ecosystem.

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Entire Pond Treatments

 Anti-Parasitic Treatments for Entire Ponds &   Their Impact on Biological Filtration

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